Flagellin (IMAGE)
Caption
Flagella, which provide motility for pathogens like S. tyhimurium, contains flagellin, which is taken up by a splenic dendritic cell (purple). A specialized flaggelin sensor NAIP5 registers the presence of flagellin and initiates the assembly of the inflammasome complex NLRC4, which triggers a cascade of events, liberating IL-18—an inflammatory interleukin—from the dendritic cell. IL-18 then migrates to a CD8+ T cell (green), where it binds with a specific receptor known as MyD88. The resulting IFN-λ secretion contributes to the clearance of the infecting pathogen by activating cellular antibacterial resistance pathways.
Credit
Figure reprinted by permission from Macmillan Publishers Ltd: <I>Nature Immunology</I>, Cellular teamwork in antibacterial innate immunity, Janelle S Ayres, Russell E Vance Volume 13 Number 2. February, 2012 Infographic by Katie Vicari.
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