The Nematode as a Window to Human Disease? (3 of 6) (IMAGE)

American Association for the Advancement of Science (AAAS)

The Nematode as a Window to Human Disease? (3 of 6)

Caption

This oocyte nucleus of an animal homozygous for an X-autosome end-to-end chromosome fusion shows five DAPI-positive bivalent chromosomes, rather than six observed for wildtype. Overlaid are microarray data showing DNA copy number for a control animal lacking fusions (top, red and blue), a breakage-fusion-bridge-like fusion (center, red and green), and fusion driven by telomere recombination (bottom, red and pink). This image relates to an article that appeared in the April 22, 2011, issue of Science, published by AAAS. The study, by Mia Rochelle Lowden, at University of North Carolina and colleagues, was titled, "DNA Synthesis Generates Terminal Duplications That Seal End-to-End Chromosome Fusions."

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