Efficacy of Treatment on Tumor-Bearing Mice (IMAGE)

Society of Nuclear Medicine and Molecular Imaging

Efficacy of Treatment on Tumor-Bearing Mice

Caption

Efficacy of 212Pb-daratumumab treatment on Rag2?/?γC?/? bearing subcutaneous xenograft of MM cells. Thirteen days after engraftment, mice received PBS, daratumumab (10 μg or 16 mg/kg), 212Pb-isotypic control (277.5 kBq), or 212Pb-daratumumab (185 or 277.5 kBq). (A) Kaplan-Meier survival analysis. Data were analyzed with log-rank test. (B) Individual tumoral growth evolution. Tumor volume was measured 3 times per week. Mice were euthanized when tumors were 1 cm3 or when 120 d of survival was reached (end of experiment).

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Images created by S. Durand-Panteix and I. Quelven-Bertin, et al, University of Limoges, CNRS, INSERM

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