Figure 1. Graphical Abstract of the Paper (IMAGE) Kanazawa University Caption Spred1 maintains hematopoietic homeostasis by controlling both of HSC self-renewal supported by ROCK activity and tumor suppression due to inactivation of ERK signaling. Spred1 deficiency under high-fat diet condition induces the activation of ERK signaling, resulting in functional HSC failure, severe anemia, and development of leukemia. The hematopoietic abnormalities are mediated by the gut microbiota dysbiosis. Credit Kanazawa University Usage Restrictions The image may only be used with appropriate caption and credit. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.