Ring Cycle (VIDEO)

Rockefeller University

Caption

The octagonal center ring of the nuclear pore complex opens when nucleoporin 58 (red) interacts with nucleoporin 54 (blue), then constricts as they separate. New research shows unstructured regions of 58 (squiggly filaments) interact with transport factors (green). This interaction makes the dilated conformation more favorable, pushing the ring to open.

Credit

The Laboratory of Cell Biology

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