Botulinum Neurotoxin Binding (IMAGE)

Howard Hughes Medical Institute

Botulinum Neurotoxin Binding

Caption

Botulinum neurotoxin hijacks synaptic vesicle recycling at neuromuscular junctions. The toxin first docks to the active zone (blue) by binding to two membrane-anchored receptors, synaptotagmin (red) and ganglioside (yellow). The toxin-receptor complexes are then internalized by endocytosis.

Credit

Courtesy of Axel Brunger/HHMI at Stanford University

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