Ovarian Follicle Production (IMAGE) Carnegie Institution for Science Caption An illustration of gene expression underlying wave1 and wave2 follicle production. Each dot on the diagram mathematically summarizes the gene expression of individual ovarian helper cells that surround developing egg cells in two-dimensional gene space. Developing cells fall into clusters indicated by a common color and clusters are present in the ovary only at single developmental times (i.e. E14.5, E16.5, etc.) indicated for cells within the dashed zones. It can be seen that each time zone houses precisely two types of follicle cells, which were found to come from future wave 1 follicles (4, odd numbers >4) or wave 2 two follicles (even numbers >4). Credit Figure is courtesy of Allan Spradling and Wanbao Niu. Underlying image purchased from Shutterstock. Composite created by Navid Marvi. Usage Restrictions With credit License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.