Non-Genetic Allelic Effects (IMAGE)
Caption
This image depicts the non-genetic allelic effects Gregg et al. found for many autosomal genes in the mouse and primate brain in our paper. The image shows the maternal (red) and paternal (blue) copies of a chromosome in three neurons. A gene on this chromosome differentially expresses it's two alleles in the depicted neurons due to epigenetic effects, further one allele is mutated (red) and one is healthy (blue). In the most brightly highlighted yellow neuron, the gene is monoallelic and only expresses the healthy, wildtype allele. In the more dimly highlighted neuron, the gene is biallelic and expresses both the healthy and the mutated allele. Finally, in the dark neuron, only the mutated allele is expressed. This image shows how non-genetic allelic effects can shape genetic architecture at the cellular level in the brain, potentially creating a complex picture of genetics for brain disorders.
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Gregg Lab
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