Induction Mechanisms of Colitogenic Macrophages (IMAGE)

_Tokyo Medical and Dental University

Induction Mechanisms of Colitogenic Macrophages

Caption

Upon inflammation, monocytes are recruited into the inflamed colon, where they become colitogenic macrophages expressing TNF-? and iNOS. Regarding the mechanisms, we found that IFN-γ acts on the recruited monocytes and phosphorylated STAT1 further induces histone acetylation at the promoter regions of the Tnf and Nos2 loci, by which they become colitogenic macrophages.

Credit

Department of Biodefense Research,TMDU

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.