Like a Key in the Lock Cepafungin I Fits into a Pocket of the Proteasome (IMAGE)

Technical University of Munich (TUM)

Like a Key in the Lock Cepafungin I Fits into a Pocket of the Proteasome

Caption

Molecules which lock the vitally important activity of the proteasome are promising candidates for new anti-cancer medicines. Cepafungin I, a poison produced by the bacterium Photorhabdus luminescens, turned out to outperform even glidobactin A, the strongest proteasome blocker so far.

Credit

Chair for Biochemistry, Technische Universitaet Muenchen

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