STAT3 Prevents Neurodegeneration (IMAGE)

Rockefeller University Press

STAT3 Prevents Neurodegeneration

Caption

A JCB study shows how the protein CNTF activates the transcription factor STAT3 (green), which lingers in the axon (blue) and helps stabilize microtubules by inhibiting a protein called stathmin (magenta). STAT3 and stathmin colocalize in axonal branch points (arrowheads) and growth cones (arrow).

Credit

Selvaraj, B.T., et al. 2012. <em>J. Cell Biol.</em> doi:10.1083/jcb.201203109

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