Summary and Comparison of the Tip-Link Protein-Protein Interaction Networks in Brush Border Microvilli and Inner Ear Stereocilia (IMAGE)

Hong Kong University of Science and Technology

Summary and Comparison of the Tip-Link Protein-Protein Interaction Networks in Brush Border Microvilli and Inner Ear Stereocilia

Caption

(A) The top panel summarizes the detailed protein interaction network governing the assembly of the inter-microvillar tip-link. Except for the extracellular cadherin repeat-mediated hetero-dimerization interaction between CDHR2 and CDHR5 identified recently by Tyska's group (Crawley et al., 2014b), the rest of the interactions marked by two-way arrows have been characterized quantitatively in this study. The bottom panel is a cartoon summary of the protein interaction network in microvilli. (B) The protein interaction network governing the inner ear stereocilia tip-link complex (also known as the USH1 complex) assembly. The figure is adapted from an earlier review by Pan and Zhang (2012). The bottom panel is a cartoon summary of the protein interaction network in stereocilia adapted from an earlier review by Lu et al. (2014).

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HKUST Division of Life Science

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