The Role of Dopamine and CRY in Regulating Diurnal/Nocturnal Behavior (IMAGE)

University of Pennsylvania School of Medicine

The Role of Dopamine and CRY in Regulating Diurnal/Nocturnal Behavior

Caption

In wild type flies (left), light promotes activity during the day. These effects of light are likely mediated by the visual system (shown by dotted lines). In addition, the Clock protein suppresses dopamine signaling, which would otherwise promote activity at night. Clock also suppresses CRY. In Clock mutant flies (right), dopamine signaling is elevated (increased extracellular dopamine, circles), which acts through CRY to drive activity at night.

Credit

Amita Sehgal, Ph.D., Perelman School of Medicine, University of Pennsylvania; <i>Genes and Development</i>

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