Preserve Fertility (IMAGE)

Goethe University Frankfurt

Preserve Fertility

Caption

Following DNA damage induced by chemo- or radiotherapy the inactive and only dimeric conformation of p63 gets modified by CHK2. This modification constitutes a recognition signal for CK1 which adds additional phosphate groups to p63 resulting in the formation of the active and tetrameric state. Active p63 initiates apoptosis in oocytes. Modified version taken from Tuppi et al. DOI: 10.1038/s41594-018-0035-7

Credit

Tuppi et al.

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