Anticancer Drug Resistance Mechanism (IMAGE) Kumamoto University Caption Extracellular vesicle (EV) Annexin A6 secreted by cancer-associated fibroblasts (CAFs) is taken up by gastric cancer cells. Annexin A6 is involved in the acquisition of anticancer drug resistance by stabilizing β1 integrin present on gastric cancer cell membrane and then activating downstream signals. Credit Dr. Takatsugu Ishimoto Usage Restrictions This image may only be used in conjunction with the accompanying release, or stories written about the work described in the release with reference to the original work. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.