PHD Controls the Epidermal Growth Factor Reptor (IMAGE)
Caption
A special PHD protein, PHD3, also controls the epidermal growth factor receptor (EGFR). In healthy cells, PHD3 responds to stressors such as a lack of oxygen by stimulating the uptake of EGF receptors into the cell interior. Growth signals are down-regulated by this internalization. This process is disrupted in tumor cells due to the loss of PHD3. As a result, the internalization of EGFR is suppressed, which leads to overactivity of EGFR signals, and thus to uncontrolled cell growth.
Credit
Garlov et al.
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