Age Related Microbiology Changes (IMAGE)
Caption
This visual abstract represents the findings of Thevaranjan et al. who, using young and old germ-free and conventional mice, demonstrate that age-related microbiota changes drive intestinal permeability, age-associated inflammation, and decreased macrophage function. Reducing TNF levels rescues microbiota changes and protects old mice from intestinal permeability.
Credit
Thevaranjan et al./<i>Cell Host & Microbe</i> 2017
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