Amyloid Binding (IMAGE) Optica Caption Researchers developed a microscopy technique that measures the location and orientation of single molecules and used it to study the structural details of amyloid protein aggregates. (a) Single-molecule localization microscopy image of a network of amyloid aggregates. (b) Image showing Nile red binding orientations to amyloid surfaces, color-coded according to the average orientation measured within each bin. (c-g) Individual orientation measurements localized along fibril backbones within the white boxes in (b). The lines are oriented and color-coded according to the direction of the estimated angle. Horizontal white scale bars are length markers, 1 micron in (a), (b) and 100 nm in (f), (g). Credit Tianben Ding, Tingting Wu and Matthew D. Lew, Washington University in St. Louis Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.