The Receptor that Protects Blood Vessels from Scarring (4 of 6) (IMAGE)

American Association for the Advancement of Science (AAAS)

The Receptor that Protects Blood Vessels from Scarring (4 of 6)

Caption

To confirm that loss of FGFR1 led to the onset of the vessel-scarring EndMT process in vivo, the researchers generated mice lacking this receptor and performed blood vessel grafting in these animals. The Figures in panel 5 reveal the increase in the thickness of the vein grafts and the increase in collagen deposition and numbers of luminal cells that resulted in these animals, compared to controls. Colocalization (yellow) of Cdh5-GFP (green) with Notch3 (red) or a-SMA (red) staining indicates EndMT. This image relates to a paper that appeared in the Sept. 23, 2014, issue of Science Signaling, published by AAAS. The paper, by Dr. Pei-Yu Chen at Yale University School of Medicine in New Haven, Conn., and colleagues was titled, 'Fibroblast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endothelium.'

Credit

Pei-Yu Chen and Lingfeng Qin

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