Newly Engineered Peptide Shows Potential as Long-Acting Anti-HIV Drug (IMAGE)

PLOS

Newly Engineered Peptide Shows Potential as Long-Acting Anti-HIV Drug

Caption

Anti-HIV-1 strategy of a long-acting fusion inhibitory peptide in combination with a broad neutralizing antibody (bNAb). The bNAb N6 may act as a biomissile for carrying a long-acting fusion inhibitory peptide IBP-CP24. N6 can directly hit HIV-1 by targeting gp120, while IBP-CP24 released from N6 can strike HIV-1 by targeting gp41, resulting in an effect of "a double-hit" by targeting both gp120 and gp41 on one virion (lower panel) or "one-stone-two-birds" by targeting gp120 on one virion and gp41 on another virion (upper panel). Therefore, combination of IBP-CP24 and N6 is expected to have synergistic anti-HIV-1 effect.

Credit

Bi W, et al. (2019)

Usage Restrictions

CC-BY: Redistribution permitted with credit

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.