Crystal Structure of Fungal Channel Nucleoporin Complex (VIDEO)

California Institute of Technology

Caption

This video features a rotating three-dimensional crystal structure of the fungal channel nucleoporin complex bound to the adaptor nucleoporin Nic96, as determined by a team of biochemists led by Caltech. This interaction is the complex's sole site of attachment to the rest of the inner ring of the NPC. The channel nucleoporin complex borders the central transport channel and fills it with filamentous structures (phenylalanine-glycine repeats) that form a diffusion barrier and provide docking sites for proteins that ferry molecules across the nuclear envelope.

Credit

Andre Hoelz/Caltech and Science

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