Incomplete Protein Networks Offer Glimpse into Related Diseases (1 of 2) (IMAGE)

American Association for the Advancement of Science (AAAS)

Incomplete Protein Networks Offer Glimpse into Related Diseases (1 of 2)

Caption

This is an illustration of the protein-protein interaction (PPI) network and two disease-modules. Proteins associated with a certain disease are not scattered randomly in the PPI network, but aggregate in local neighborhoods or "disease modules." The network-based distance between modules is related to the pathobiological similarity of the corresponding diseases. The nodes colored in purple and yellow correspond to proteins associated with asthma and COPD (Chronic Obstructive Pulmonary Disease). The two related respiratory diseases reside in overlapping neighborhoods of the PPI network. This material relates to papers that appeared in the Feb. 20, 2015 issue of Science, published by AAAS. The paper, by Jörg Menche at Northeastern University in Boston, MA, and colleagues was titled, "Uncovering disease-disease relationships through the incomplete interactome."

Credit

[Credit: Visualization by Mauro Martino and Alec Pawling; Data Analysis by Menche <i>et al.</i> (Science 2015)]

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