Sequential Intravital Multiphoton Microscopy of An Autofluorescence Chemotherapeutic Agent (IMAGE)

Acoustical Society of America

Sequential Intravital Multiphoton Microscopy of An Autofluorescence Chemotherapeutic Agent

Caption

Sequential intravital multiphoton microscopy of an autofluorescence chemotherapeutic agent (red) in BT474-Gluc brain tumors (green) after FUS-mediated blood-brain barrier disruption (FUS-BBBD). White arrows show increased drug extravasation and penetration after FUS-BBBD (white arrows). Yellow arrows show increased doxorubicin transmembrane transport in endothelial cells after FUS-BBBD. The bottom left and right images were collected 2 and 5 minutes after drug administration respectively. Scale bar 30 μm.

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Proceedings of the National Academy of Sciences

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