Trophoblasts Refractory to Zika Infection (IMAGE) Cell Press Caption This visual abstract depicts the Bayer and Lennemann et al. finding that primary human placental trophoblasts are refractory to ZIKV infection due to their constitutive release of antiviral type III interferons, which also serves to protect nonplacental cells. These data suggest that rather than directly infecting the placenta, ZIKV likely uses alternative strategies to cross the placenta. Credit Bayer and Lennemann et al./<i>Cell Host & Microbe</i> 2016 Usage Restrictions Credit Required. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.