Trophoblasts Refractory to Zika Infection (IMAGE)

Cell Press

Trophoblasts Refractory to Zika Infection

Caption

This visual abstract depicts the Bayer and Lennemann et al. finding that primary human placental trophoblasts are refractory to ZIKV infection due to their constitutive release of antiviral type III interferons, which also serves to protect nonplacental cells. These data suggest that rather than directly infecting the placenta, ZIKV likely uses alternative strategies to cross the placenta.

Credit

Bayer and Lennemann et al./<i>Cell Host & Microbe</i> 2016

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