Graphical Abstract (IMAGE) Texas Children's Hospital Caption Chronic infection and inflammation promotes promotes differentiation in normal HSCs while it promotes self-renewal in Dnmt3a-mutant HSCs leading to aberrant immune responses to infections and inflammatory stress. Credit Hormaechea-Agulla et al., Cell Stem Cell, 2021, Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.