Studying Mice on Psychostimulants to Detect a Dopamine Receptor's Function (3 of 5) (IMAGE)

American Association for the Advancement of Science (AAAS)

Studying Mice on Psychostimulants to Detect a Dopamine Receptor's Function (3 of 5)

Caption

Blunted response to methamphetamine in D4.7 mice. (A to D) Extracellular concentrations of DA in the nucleus accumbens were measured at 10-min intervals using in vivo microdialysis before and after intraperitoneal injections of meth [1 and 3 mg/kg, (A) and (B), respectively] or cocaine [10 and 30 mg/kg, (C) and (D), respectively] in wild type (black symbols/lines) and D4.7 mice (blue symbols/lines). This material relates to a paper that appeared in the Jan. 11, 2017, issue of Science Advances, published by AAAS. The paper, by J. Bonaventura at National Institutes of Health in Baltimore, Md., and colleagues was titled, 'Key role of the dopamine D4 receptor in the modulation of corticostriatal glutamatergic neurotransmission.'

Credit

Bonaventura et al. <i>Sci. Adv.</i> 2017;3:e1601631

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