Vertical <i>Escherichia coli</i> (IMAGE) Rice University Caption Rice University scientists engineered a synthetic genetic clock inside a mutant <i>Escherichia coli</i> bacteria that keeps time despite rising or falling temperature. In an experiment, the researchers isolated a small number of engineered bacteria under a fluorescent microscope and captured images over three hours as a single cell (yellow arrow) oscillated at a regular clip between states despite changing conditions. They found altering one amino acid to make a regulator protein sensitive to temperature provided the right feedback to the bacteria's circadian clock. Credit Bennett Lab/Rice University Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.