Oral Therapy, Improved Outcome (IMAGE) Cincinnati Children's Hospital Medical Center Caption PET-CT images of a 10-month-old child with Langerhans cell histiocytosis (LCH) show increased disease activity in the bones (left image). Three months after the start of oral therapy with the drug dabrafenib, the image on the right shows near complete resolution of disease activity. The child was part of a study in JCI Insight from Cincinnati Children's summarizing outcomes of off-label oral therapy in patients with histiocytoses that were resistant to chemotherapy. Study authors recommend additional study, including clinical trials to further test the therapeutic approach. Credit Cincinnati Children's Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.