Figure 3 (IMAGE)

Waseda University

Figure 3

Caption

When Aurora B, PP2A, and SET function accurately as tension sensors, the maintained balance of phosphorylation at the kinetochore leads to precise chromosome alignment and segregation. However, the abnormal tension sensor leads to chromosome missegregation, thereby causing cancer and genetic diseases such as Down's syndrome.

Credit

Terada Laboratory, Waseda University

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