Schematic of Truncated Replay in SCN2A+/- Mice (IMAGE)

RIKEN

Schematic of Truncated Replay in SCN2A+/- Mice

Caption

As mice perform a spatial memory task they generate a map of space coded by place cell activity represented here as coloured tiles. During periods of rest and sleep, these sequences are replayed repetitively in events called sharp-wave ripples (depicted in the speech bubble) leading to memory consolidation. In SCN2A+/- mutant mice these replayed sequences are incomplete, with the partially consolidated memory unable to support correct behavioral performance in upcoming trials.

Credit

RIKEN National Science Institute of Japan

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credit RIKEN National Science Institute of Japan

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