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Fig. 1 The number of IL-17A and MCT double positive cells correlated with the ratio of fibrotic area in the peritoneal tumors. This means IL-17A derived from mast cells may contribute tumor fibrosis. MCT: mast cell tryptase<br /> Fig. 2 Expression of FAP was found in HPMCs treated with IL-17A using immunofluorescence staining. This means HPMCs were transformed into myofibroblast, so called CAF, by IL-17A. FAP: fibroblast activation protein as a marker of CAF. HPMCs: human peritoneal mesothelial cells. CAF: cancer associated fibroblast.<br /> Fig. 3 Nude mouse was inoculated with human gastric cancer cell line MKN45-P cells intraperitoneally at day 0. Recombinant mouse IL-17A was administrated intraperitoneally at day 1, 3 and 7. Large and many peritoneal nodules were found at day 14.<br /> Fig. 4 Fibrosis in the peritoneal nodules was recognized as blue area by azan staining. Fibrous area in the tumor treated with IL-17A was wider than that without IL-17A.<br />
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Kanazawa University
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