Tpr Excluded from Nucleus of HGPS Patient (IMAGE) Rockefeller University Press Caption A new study in The Journal of Cell Biology suggests that the fatal disease HGPS might result from the selective exclusion of large proteins or protein complexes from the nucleus. One such protein, Tpr (red), accumulates in the nuclei of cells from a healthy person (left), but it remains in the cytoplasm of cells from an HGPS patient (right). Credit Snow, C.J., et al. 2013. <em>J. Cell Biol</em>. doi:10.1083/jcb.201212117 Usage Restrictions Reporters may freely use these materials in news coverage, with the appropriate credit information. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.