Cyclic Decapeptide (IMAGE) Tokyo Medical and Dental University Caption This is a cyclic decapeptide, which mimics the dimerization arm of the EGF receptor (EGFR), was previously found to be captured into cells. The authors have found the promising potential of this peptide as an intracellular delivery vehicle directed to EGFR-positive cells. The cellular delivery of the proapoptotic domain (PAD) peptide was challenged by conjugation with the above cyclic peptide. The cellular uptake of the conjugated peptide, which was composed of the cyclic peptide, the PAD peptide and a linker cleavable with a protease, was evaluated by treatment of EGFR-positive cells. Significant suppression of proliferation by the conjugated peptide was shown in a cell viability assay. Credit Department of Medicinal Chemistry,TMDU Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.