Accelerating Development of New Sickle Cell Disease Treatments (2 of 2) (VIDEO)

American Association for the Advancement of Science (AAAS)

Caption

We developed a kinetic model to predict the fraction of sickled RBCs according to patient-specific inputs and examine the therapeutic efficacy of anti-sickling agents. We show that the fraction of sickled RBCs decreases with the increase of anti-sickling agent concentration. This material relates to a paper that appeared in the August 21st, 2019, issue of Science Advances, published by AAAS. The paper, by L. Lu at Brown University in Providence, RI, and colleagues was titled, "Quantitative prediction of erythrocyte sickling for the development of advanced sickle cell therapies."

Credit

Lu Lu, Zhen Li, He Li, Xuejin Li, George Karniadakis

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