Gut Microbes and Autoimmune Eye Disease (IMAGE) Cell Press Caption It is unknown where and how T cells reactive to self antigens residing behind blood-tissue barriers first become activated. New research shows that retina-specific T cells receive an activation signal in the gut from an antigen dependent on commensal microbiota and trigger autoimmunity in the eye. Credit Horai and Zarate-Blades et al./<i>Immunity</i> 2015 Usage Restrictions Credit Required. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.