Novel Mutation Affects Brain-Folding Protein (1 of 4) (IMAGE)

American Association for the Advancement of Science (AAAS)

Novel Mutation Affects Brain-Folding Protein (1 of 4)

Caption

The cerebral cortical development gene GPR56 has multiple alternative promoters. Mutation of a cis-regulatory element impairs one of the promoters, leading to abnormal gyral patterning in the lateral frontal cortex. A 23-kb upstream region of human GPR56 drives green fluorescent protein expression throughout the transgenic mouse neocortex (top), and the mutation eliminates expression from lateral cortex (bottom). This image relates to a paper that appeared in the Feb. 14, 2014, issue of Science, published by AAAS. The paper, by Byoung-il Bae at Howard Hughes Medical Institute in Boston, Mass., and colleagues was titled, "Evolutionarily Dynamic Alternative Splicing of GPR56 Regulates Regional Cerebral Cortical Patterning."

Credit

[Image courtesy of Byoung-il Bae]

Usage Restrictions

Please cite the owner of the image when publishing. This image may be freely used by reporters as part of news coverage, with proper attribution. Non-reporters must contact <i>Science</i> for permission.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.