Keeping the Immune System in Check After Organ Transplants (1 of 5) (IMAGE)

American Association for the Advancement of Science (AAAS)

Keeping the Immune System in Check After Organ Transplants (1 of 5)

Caption

This shows the presence of IDO, or indoleamine dioxigenase, molecules (in green), expressed by blood vessels in kidney grafts in recipients that received a CD28-blocking drug. This is meaningful since IDO is by itself an immune system molecule generated by the interaction of T-cells with other cell types (here, smooth muscle cells). This image relates to an article that appeared in the February 3, 2010, issue of Science Translational Medicine. The study, by Dr. Poirier of INSERM in Nantes, France, and colleagues was titled, "Inducing CTLA-4-Dependent Immune Regulation by Selective CD28 Blockade Promotes Regulatory T Cells in Organ Transplantation."

Credit

Image © <i>Science</I>/AAAS

Usage Restrictions

Please cite the owner of the image when publishing. This image may be freely used by reporters as part of news coverage, with proper attribution. Non-reporters must contact <i>Science</I> for permission.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.