SAFit Ligand (IMAGE)
Caption
The SAFit ligand (blue/green) is a highly selective inhibitor of FKBP51 (gray), a risk factor for stress-related psychiatric disorders. The binding of SAFit induces a conformational change (red protein side chain) in FKBP51, but not in its very similar functional counterplayer FKBP52.
Credit
MPI of Psychiatry / Felix Hausch
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