POSTECH Researchers Find Sensory Neurons Modulate Aging Hormone (IMAGE)

Pohang University of Science & Technology (POSTECH)

POSTECH Researchers Find Sensory Neurons Modulate Aging Hormone

Caption

Lee and Artan's research was featured as the cover title of Genes & Development. Inhibition of sensory neurons in C. elegans increases life span by decreasing the level of an insulin-like peptide, INS-6, and subsequently activating the FOXO transcription factor. Shown here is a fluorescence analysis of transgenic worms deficient in the sensory transduction gene tax-4 that are expressing either red fluorescent protein (RFP) or green fluorescent protein (GFP) fused to promoters of the FOXO targets dod-11 or sod-3, respectively. Inhibition of sensory neural function by tax-4 mutation increases dod-11 and sod-3 expression in the nonneuronal as well as neuronal tissues.

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Genes & Development (CSH Press)

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