Results of the Study (IMAGE) Josep Carreras Leukaemia Research Institute Caption A: Co-localisation of CD138 in myeloma cells with histone H2AZ. In the image above myeloma cells are shown alone, and in the image below after the addition of histone H2AZ. B: Anti-myeloma activity of histone H2AZ. The bioluminescent signal emitted by myeloma cells is shown in mice that received tumor cells alone, or were treated with histone H2AZ. C. Immunoregulatory activity of histones on T lymphocytes released by NK cells. Myeloma cells were co-cultured with NK cells derived from umbilical cord blood (CB-NK) and the released supernatant containing histones (SIPs siRNA) ctrl). On the other hand, NK cells which histone expression (SIPs siRNA Histones) had been decreased were used, D. The supernatants were added to T lymphocytes co-cultured with MM cells, showing that the histones in this supernatant increase the formation of Clusters between T lymphocytes and myeloma cells, and the anti-myeloma activity of T lymphocytes. Credit Beatriz Martín Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.