Salk Institute -- Evans lab -- ERRy Muscles (IMAGE)

Salk Institute

Salk Institute -- Evans lab -- ERRy Muscles

Caption

Top left: PGC1 deficiency leads to severe muscle damage, evidenced by numerous centralized nuclei (highlighted with arrows), which is likely due to impaired mitochondrial energy metabolism (bottom left: blue staining shows impaired mitochondrial activity). Such muscle damage and mitochondrial impairment is largely rescued by ERRγ overexpression (top and bottom right).

Credit

Salk Institute

Usage Restrictions

with credit and related coverage.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.