Relaxin Treated Ventricular Tissue (IMAGE)

University of Pittsburgh

Relaxin Treated Ventricular Tissue

Caption

Left ventricular tissue sections (7-μm thick) from aged rat hearts (24 months old) were labeled with the nuclear stain (DAPI-blue) and an antibody against β-catenin (green). Rats were treated with Relaxin (0.4 mg/kg/day for 2-weeks) (left panel) or with the control vehicle (sodium acetate) (right panel) and the tissue sections were imaged by confocal microscopy (600X magnification). Relaxin treatment (left) produced a marked positive remodeling of aged ventricles with a reduction of cell hypertrophy, improved organization of myofibrils and cell membrane compared to untreated, control aged hearts (right).

Credit

Dr. Guillermo Romero

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