A Model for the Recycling of Synaptic Vesicles (IMAGE)

University of California - San Francisco

A Model for the Recycling of Synaptic Vesicles

Caption

The data in Hua et al. support a model for the recycling of synaptic vesicles proposed by the Edwards lab several years ago. The model predicts that different synaptic vesicle pools derive from different endocytic pathways. Recycling pool vesicles appear to originate from clathrin- and adaptor protein 2 (AP2)-dependent endocytosis, and resting pool vesicles from a pathway involving the adaptor protein AP-3.

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Graphic by S. Voglmaier and R. Edwards/UCSF

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