Optimizing Treatment Protocols when Diagnostics are Costly (IMAGE)

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Optimizing Treatment Protocols when Diagnostics are Costly

Caption

Optimal treatment strategies in the context of 'treatment for prevention' against HIV-1. Without medical treatment (upper panel) HIV-1 infected individuals have a high viral titer, which is related to a high probability to infect a sero-discordant partner after sexual contact. In contrast, diagnostic-guided (middle panel) and pro-active treatment switching strategies (lower panel) can durably suppress the virus in an HIV-1 infected individual, thus reducing the probability that the individual spreads the infection.

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Sulav Duwal

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