Enterohemorrhagic Ecoli Pathogenesis (IMAGE)

Wyss Institute for Biologically Inspired Engineering at Harvard

Enterohemorrhagic Ecoli Pathogenesis

Caption

Human colon epithelia are much more prone to be damaged and detach from the surface of a colon epithelial channel in a Colon Chip when exposed to enterohemorrhagic E. coli (EHEC) in the presence of human microbiome metabolites (Hmm) compared to mouse microbiome metabolites (Mmm). The top row of contrast images show colon epithelia grown in Organ Chips that have been exposed (from left to right) to Hmm, Mmm, Hmm together with EHECs, and Mmm together with EHECs. The columns below present the surface areas (yellow) of the intestinal luminal channels in which human colon epithelial cells (blue) were grown and exposed to the same conditions.

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Wyss Institute at Harvard University

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