Biomarker Helps Identify 'Window of Opportunity' for Cancer Chemotherapy Timing (IMAGE)

Elsevier

Biomarker Helps Identify 'Window of Opportunity' for Cancer Chemotherapy Timing

Caption

Initiation of tumor angiogenesis up-regulates PSF1 promoter activity in endothelial cells (ECs). A: Skin vasculature 3 days after B16 melanoma cell injection into the mouse. White dashed line indicates localization of tumor. Arrows indicate EGFP-positive ECs around the tumor. Two pieces of images were put together and edited to one piece. B: Sprouting new capillary from preexisting blood vessels around the tumor. White dashed line indicates localization of tumor. Arrows indicate budding ECs that express EGFP and CD31 (red). C: Flow cytometric analysis of endothelial PSF1 promoter activity in skin tissues around tumors 3 days after tumor cell inoculation. PSF1 promoter activity in ECs is increased in the skin vasculature, with B16 tumor inoculation (orange) relative to skin from wild type (WT; red) or transgenic (Tg; blue) mice in the steady state.

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<i>The American Journal of Pathology</i>

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