Fig. 1 (IMAGE)

DGIST (Daegu Gyeongbuk Institute of Science and Technology)

Fig. 1

Caption

Schematic summary. Under the condition of chronic inflammation, TNF-α -expressing M2-like macrophages are accumulated in LP of aging animal intestine. The TNF-α upregulates ANG2 expression in microvascular endothelial cells that skews the angiopoetin-TIE-2 signaling in neighboring vascular EC to inflammatory settings by removing supportive structures: microvessel-associated pericytes and adherens junction protein vascular endothelial (VE)-cadherin at the cell-cell junction. Consequently, microvessels in aged mice became leaky for recruitment of immune cells.

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DGIST

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