Disruption of cytokine signals by HTLV-1 bZIP factor (HBZ) (IMAGE)

Kumamoto University

Disruption of cytokine signals by HTLV-1 bZIP factor (HBZ)

Caption

In HBZ-expressing CD4-positive T cells, differentiation into T cells that resemble regulatory T lymphocytes is enhanced and production of the immunosuppressive cytokine, IL-10, is increased. Furthermore, HBZ modulates the IL-10 signal by the binding of HBZ to STAT1/3 protein, and is thought to promote cell proliferation.

Credit

Associate Professor Jun-ichirou Yasunaga

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