Blocking Wnt signalling leads cancer cells to undergo senescence (IMAGE)
Caption
Wnt signalling dampens RAS-MAPK signalling, enabling cancer cells to grow steadily instead of heading towards the premature ageing that can be caused by excessive RAS-MAPK signalling. When researchers inhibited Wnt signalling the anti-cancer drug ETC-159, they found that the reactivation of the hyperactive RAS-MAPK pathway led the cancer cells to undergo senescence, which is an ageing process that results in arrested growth.
Credit
Duke-NUS Medical School
Usage Restrictions
The image may only be used with the prescribed caption and credit.
License
Licensed content