Peptide Therapy Safely Lowers Blood Triglycerides in Animals (1 of 2) (IMAGE)

American Association for the Advancement of Science (AAAS)

Peptide Therapy Safely Lowers Blood Triglycerides in Animals (1 of 2)

Caption

Four microsecond-long molecular dynamics simulation of apolipoprotein C-II interacting with a trilayer, mimicking a triglyceride-rich lipoprotein. Carbon atoms of triglycerides and phospholipids are shown in yellow and gray, respectively. N-terminal, middle, and C-terminal domains of apoC-II are shown in blue, cayan, and red, respectively. This material relates to a paper that appeared in the Jan. 29, 2019, issue of Science Translational Medicine, published by AAAS. The paper, by A. Wolska at National Heart, Lung, and Blood Institute, NIH in Bethesda, MD; and colleagues was titled, "A dual apolipoprotein C-II mimetic-apolipoprotein C-III antagonist peptide lowers plasma triglycerides."

Credit

[Credit: Mohsen Pourmousa, National Institutes of Health]

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